The boost was because of the recognition of $7.8 million of deferred forodesine-related revenue in the first quarter 2012 previously, and also the recognition of $3.3 million royalty income from Shionogi & Co., Ltd. The aggregate revenue boost was partially offset by a reduction in peramivir collaboration income from BARDA/HHS because of a reduced amount of peramivir advancement activity in 2012, in comparison with 2011. R&D expenses reduced to $51.2 million in 2011. A reduction in 2012 advancement costs linked to the ulodesine and peramivir applications had been partially offset by higher BCX5191 and BCX4161 advancement costs, when compared with 2011. Expenses for 2012 included the reputation of $1.9 million of noncash, previously deferred expenses from the transfer of forodesine advancement activity to Mundipharma International Holdings Ltd.Children report more frequent sleep problems than parents acknowledge Elementary-school-aged children commonly knowledge sleep problems, but small research has addressed the good reasons for this phenomenon. A new study finds that kids of this age say they have sleep difficulties much more often than their parents report such problems. The results, published in the November/December 2006 issue of the journal Kid Development, are based on questionnaires completed by 300 pairs of 8-year-old twins and their parents in Wales and England. The researchers thought we would research twins because such research provide an possibility to appear at both genetic and environmental influences on a variety of sleep characteristics and complications.