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This trial is ongoing and the positive outcomes are producing enthusiasm for a larger Phase-III trial which is currently underway. This trial is named MARIANNE, and it evaluates taxane plus trastuzumab against T-DM1 as administered in this scholarly study, with a third option getting pertuzumab plus T-DM1, another novel anti-HER2 agent, said Prof Perez. I feel privileged to continue our collaborative function to help bring brand-new and better therapeutic choices for patients. Firstly, they concur that in arriving years chemotherapy could be replaced by a much less toxic compound. Indeed, in today’s study, the rates of serious adverse occasions were much lower in patients given T-DM1 when compared to chemotherapy arm. These results suggest that, with the same efficacy, T-DM1 could reduce the toxicities related to chemotherapy dramatically.